Paget’s disease of the bone is a rather unusual condition in which calcium disappears from the structure. The exact cause of the condition is not known. The parathyroid glands have been studied, but cases of Paget’s disease have been found in which the parathyroid glands were entirely normal. Questions have also been raised as to [...]

In general, it takes five half-lives to achieve a steady state of a relatively consistent blood level of a drug between doses. After one dose of a medicine, let’s say that the blood level is 8. One half-life later the level has decreased. If a second dose is then given, the blood level rises. You [...]